GEOapplication/xmlftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE325nnn/GSE325196/primaryOK200OtherHomo sapiens Expression profiling by high throughput sequencingOtherhttps://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE325196GEOGSEfalseSingle Nuclei and Spatial Transcriptomic Datasets in Brain MetastasesWe performed single nuclei and spatial transcriptomic sequencing on a cohort of solid tumor human brain metastasis specimens resected at Duke University Medical Center from 1998 to 2022. This includes 23 single nuclei specimens, 12 Visium standard specimens, and 4 Xenium specimens. These samples encompass metastases from lung cancer, breast cancer, melanoma, and sarcoma primaries. Analysis of these data revealed novel tumor-microenvironment cell-cell interactions associated with patient survival.2026/05/23GSE325196GSM9597721GSM9597720GSM9597723GSM9597722GSM9597725GSM9597703GSM9597702GSM9597724GSM9597716GSM9597715GSM9597718GSM9597717GSM9597719GSM9597730GSM9597732GSM9597710GSM9597731GSM9597734GSM9597712GSM9597711GSM9597733GSM9597714GSM9597736GSM9597735GSM9597713GSM9597705GSM9597727GSM9597726GSM9597704GSM9597707GSM9597729GSM9597728GSM9597706GSM9597709GSM959770824676325196Homo sapiens