GEOapplication/xmlftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE325nnn/GSE325236/primaryOK200TranscriptomicsMus musculusExpression profiling by high throughput sequencinghttps://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE325236GEOGSEfalseBile acids mediate liver-bone marrow crosstalkThis study examines the impact of tumor presence on bone marrow hematopoiesis in mouse models of liver cancer. Using a Hepa1-6 xenograft model in C57BL/6 mice, hematopoietic stem and progenitor cell populations were analyzed by flow cytometry. Although overall HSPC frequencies did not differ between tumor-bearing and control mice, tumor size positively correlated with HSPC numbers. RNA-seq comparison between xenograft and DEN-induced liver tumors revealed distinct transcriptomic profiles, indicating that xenograft tumors do not fully recapitulate the liver tumor microenvironment.2026/04/12GSE325236GSM9598238GSM9598239GSM9598240GSM9598241GSM959824224247325236Mus musculus