{"database":"GEO","file_versions":[{"headers":{"Content-Type":["application/json"]},"body":{"files":{"Other":["ftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE325nnn/GSE325258/"]},"type":"primary"},"statusCode":"OK","statusCodeValue":200}],"scores":null,"additional":{"omics_type":["Transcriptomics"],"species":["Homo sapiens"],"gds_type":["Expression profiling by high throughput sequencing"],"full_dataset_link":["https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE325258"],"repository":["GEO"],"entry_type":["GSE"],"additional_accession":[]},"is_claimable":false,"name":"Residual p53 in HPV positive cervical cancer cells has gain of function properties","description":"Human papillomavirus (HPV)-positive cervical cancer cells retain residual p53 despite E6-mediated degradation. To investigate whether this residual p53 has gain-of-function properties, CRISPR/Cas9 was used to generate p53 knockout HeLa clones and compare them with a WT control clone. RNA-seq profiling identified transcriptomic changes associated with loss of residual p53.","dates":{"publication":"2026/05/13"},"accession":"GSE325258","cross_references":{"GSM":["GSM9598554","GSM9598555","GSM9598552","GSM9598553","GSM9598550","GSM9598551"],"GPL":["24676"],"GSE":["325258"],"taxon":["Homo sapiens"]}}