{"database":"GEO","file_versions":[{"headers":{"Content-Type":["application/json"]},"body":{"files":{"Other":["ftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE325nnn/GSE325279/"]},"type":"primary"},"statusCode":"OK","statusCodeValue":200}],"scores":null,"additional":{"omics_type":["Transcriptomics"],"species":["Homo sapiens"],"gds_type":["Expression profiling by array"],"full_dataset_link":["https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE325279"],"repository":["GEO"],"entry_type":["GSE"],"additional_accession":[]},"is_claimable":false,"name":"ALDH1 inhibitor, DIMATE, Preserves Immune Function While Inducing Immunogenic Remodelling in AML","description":"DIMATE Preserves Immune Cells in AML Our study provides a comprehensive characterization of the immuno‑pharmacological effects of DIMATE, a selective ALDH1 inhibitor currently evaluated in the First‑in‑Human ODYSSEY trial. We show that DIMATE preserves the core functions of circulating immune populations—including PBMCs, T cells, NK cells, and phagocytes—while inducing a coordinated pro‑inflammatory and ER‑stress response in AML cells that culminates in the exposure of ecto‑calreticulin, a canonical hallmark of immunogenic cell death (ICD).","dates":{"publication":"2026/07/01"},"accession":"GSE325279","cross_references":{"GSM":["GSM9599483","GSM9599484","GSM9599481","GSM9599482","GSM9599487","GSM9599488","GSM9599485","GSM9599486"],"GPL":["16699"],"GSE":["325279"],"taxon":["Homo sapiens"]}}