GEOapplication/xmlftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE325nnn/GSE325279/primaryOK200TranscriptomicsHomo sapiensExpression profiling by arrayhttps://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE325279GEOGSEfalseALDH1 inhibitor, DIMATE, Preserves Immune Function While Inducing Immunogenic Remodelling in AMLDIMATE Preserves Immune Cells in AML Our study provides a comprehensive characterization of the immuno‑pharmacological effects of DIMATE, a selective ALDH1 inhibitor currently evaluated in the First‑in‑Human ODYSSEY trial. We show that DIMATE preserves the core functions of circulating immune populations—including PBMCs, T cells, NK cells, and phagocytes—while inducing a coordinated pro‑inflammatory and ER‑stress response in AML cells that culminates in the exposure of ecto‑calreticulin, a canonical hallmark of immunogenic cell death (ICD).2026/07/01GSE325279GSM9599483GSM9599484GSM9599481GSM9599482GSM9599487GSM9599488GSM9599485GSM959948616699325279Homo sapiens