{"database":"GEO","file_versions":[{"headers":{"Content-Type":["application/json"]},"body":{"files":{"Other":["ftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE325nnn/GSE325333/"]},"type":"primary"},"statusCode":"OK","statusCodeValue":200}],"scores":null,"additional":{"omics_type":["Transcriptomics"],"species":["Homo sapiens"],"gds_type":["Expression profiling by high throughput sequencing"],"full_dataset_link":["https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE325333"],"repository":["GEO"],"entry_type":["GSE"],"additional_accession":[]},"is_claimable":false,"name":"RNA-seq analysis of human peripheral blood Treg cells stratified into four equal fractions according to CD38 intensity","description":"Sensitivity of regulatory T cells (Tregs) to extracellular nucleotides such as ATP and NAD⁺ differs substantially between mice and humans. Mouse Tregs undergo robust apoptosis in response to even low concentrations of ATP or NAD⁺, whereas human Tregs show markedly reduced sensitivity to these nucleotides. In our preliminary analyses, however, we observed that a subset of human Tregs expressing low levels of CD38 exhibited increased sensitivity to ATP/NAD⁺. To investigate the molecular mechanisms underlying this enhanced sensitivity, human peripheral blood Tregs were stratified into four fractions based on CD38 expression levels and subjected to RNA sequencing (RNA-seq) analysis.","dates":{"publication":"2026/05/15"},"accession":"GSE325333","cross_references":{"GSM":["GSM9600923","GSM9600934","GSM9600936","GSM9600925","GSM9600930","GSM9600932","GSM9600921","GSM9600927","GSM9600938","GSM9600929","GSM9600918","GSM9600919"],"GPL":["24676"],"GSE":["325333"],"taxon":["Homo sapiens"]}}