{"database":"GEO","file_versions":[{"headers":{"Content-Type":["application/json"]},"body":{"files":{"Other":["ftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE325nnn/GSE325386/"]},"type":"primary"},"statusCode":"OK","statusCodeValue":200}],"scores":null,"additional":{"omics_type":["Transcriptomics"],"species":["Mus musculus"],"gds_type":["Expression profiling by high throughput sequencing"],"full_dataset_link":["https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE325386"],"repository":["GEO"],"entry_type":["GSE"],"additional_accession":[]},"is_claimable":false,"name":"Social hierarchy shapes behavioral and transcriptional responses to chronic stress and ketamine in male mice","description":"Chronic stress is a major risk factor for psychiatric disorders, yet the mechanisms underlying individual variability in stress vulnerability and treatment response remain poorly understood. Here, we combined a novel behavioral phenotyping system with high-throughput gene expression profiling to examine how chronic stress and ketamine treatment interact over time. Bulk RNA sequencing was performed in the medial prefrontal cortex and ventral hippocampus, revealing a hierarchy-dependent transcriptional response with 141 differentially expressed genes in the medial prefrontal cortex of dominant, ketamine-treated mice, enriched in synaptic and postsynaptic compartments. These findings identify synaptic remodeling as a substrate for ketamine’s sustained antidepressant effects and underscore social rank as a critical factor when dissecting molecular responses to stress and treatment.","dates":{"publication":"2026/07/29"},"accession":"GSE325386","cross_references":{"GSM":["GSM9602162","GSM9602161","GSM9602164","GSM9602163","GSM9602160","GSM9602129","GSM9602126","GSM9602125","GSM9602169","GSM9602128","GSM9602127","GSM9602122","GSM9602166","GSM9602165","GSM9602121","GSM9602168","GSM9602124","GSM9602123","GSM9602167","GSM9602151","GSM9602195","GSM9602150","GSM9602194","GSM9602153","GSM9602197","GSM9602196","GSM9602152","GSM9602191","GSM9602190","GSM9602193","GSM9602192","GSM9602159","GSM9602158","GSM9602199","GSM9602155","GSM9602154","GSM9602198","GSM9602157","GSM9602156","GSM9602140","GSM9602184","GSM9602183","GSM9602142","GSM9602186","GSM9602185","GSM9602141","GSM9602180","GSM9602182","GSM9602181","GSM9602148","GSM9602147","GSM9602149","GSM9602188","GSM9602144","GSM9602143","GSM9602187","GSM9602146","GSM9602145","GSM9602189","GSM9602173","GSM9602172","GSM9602131","GSM9602175","GSM9602130","GSM9602174","GSM9602171","GSM9602170","GSM9602137","GSM9602136","GSM9602139","GSM9602138","GSM9602133","GSM9602177","GSM9602176","GSM9602132","GSM9602179","GSM9602135","GSM9602134","GSM9602178"],"GPL":["34290"],"GSE":["325386"],"taxon":["Mus musculus"],"PMID":["[42495548]"]}}