{"database":"GEO","file_versions":[{"headers":{"Content-Type":["application/json"]},"body":{"files":{"Other":["ftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE325nnn/GSE325467/"]},"type":"primary"},"statusCode":"OK","statusCodeValue":200}],"scores":null,"additional":{"omics_type":["Other"],"species":["Mus musculus"],"gds_type":[" Expression profiling by high throughput sequencing","Other"],"full_dataset_link":["https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE325467"],"repository":["GEO"],"entry_type":["GSE"],"additional_accession":[]},"is_claimable":false,"name":"4-1BBL signaling aids B cell activation but limits proliferation during experimental malaria","description":"Several costimulatory and coinhibitory signaling axis have been reported to modulate anti-Plasmodium immune response, albeit the precise role of 4-1BB:4-1BBL axis has yet to be investigated. Here, we show that while complete loss of 4-1BB resulted in heightened parasite burden, impaired germinal center (GC) responses and memory B cell (MBC) recall. The absence of 4-1BBL however, minimally affected parasite load or GC responses, while disrupting humoral immune memory. Strikingly, therapeutic blockade of 4-1BBL early during infection derailed both humoral effector and memory response phenocopying 4-1BB-/- data, an effect that was absent when 4-1BBL was blocked at effector timepoints. Importantly, 4-1BBL blockade any timepoint during the course of infection invariably compromised MBC recall even when the GC response remained intact. Our results indicate that 4-1BBL signaling is required for optimal B cell activation but, its absence, paradoxically leads to expansion of a highly proliferative cell population while shrinking the MBC population. Our study highlights the pivotal role of 4-1BBL signaling in governing B cell responses during Plasmodium infection.","dates":{"publication":"2026/07/01"},"accession":"GSE325467","cross_references":{"GSM":["GSM9604451","GSM9604452","GSM9604450","GSM9604449","GSM9604457","GSM9604455","GSM9604456","GSM9604453","GSM9604454"],"GPL":["34290"],"GSE":["325467"],"taxon":["Mus musculus"]}}