GEOapplication/xmlftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE325nnn/GSE325546/primaryOK200TranscriptomicsRattus norvegicusExpression profiling by high throughput sequencinghttps://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE325546GEOGSEfalseThe immune response to a biodegradable polymer and corresponding collagen regenerationIn this study, we used RNA sequencing to investigate the molecular mechanisms underlying site-specific tissue regeneration induced by an injectable thermosensitive PLGA-PEG-PLGA hydrogel (T-gel) in rats. We compared the transcriptomic profiles of skin tissue following intradermal or subcutaneous injection of T-gel, with saline injections at corresponding sites as controls. This is evidenced by a greater number of differentially expressed genes and a significant enrichment of extracellular matrix organization and collagen biosynthesis pathways in the intradermal group compared to the subcutaneous group.2026/04/22GSE325546GSM9608215GSM9608226GSM9608227GSM9608216GSM9608217GSM9608228GSM9608229GSM9608218GSM9608219GSM9608208GSM9608209GSM9608230GSM9608231GSM9608220GSM9608221GSM9608210GSM9608211GSM9608222GSM9608223GSM9608212GSM9608213GSM9608224GSM9608214GSM960822524688325546Rattus norvegicus[42006002]