{"database":"GEO","file_versions":[{"headers":{"Content-Type":["application/json"]},"body":{"files":{"Other":["ftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE325nnn/GSE325555/"]},"type":"primary"},"statusCode":"OK","statusCodeValue":200}],"scores":null,"additional":{"omics_type":["Transcriptomics"],"species":["Mus musculus"],"gds_type":["Expression profiling by high throughput sequencing"],"full_dataset_link":["https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE325555"],"repository":["GEO"],"entry_type":["GSE"],"additional_accession":[]},"is_claimable":false,"name":"Inhibition of IGF1R in Early MMTV-Wnt1 Mammary Tumors: A Transcriptomic Analysis","description":"Basal-like breast cancers are aggressive and difficult to treat clinically. Tumors of this subtype have decreased expression of the insulin-like growth factor 1 receptor (IGF1R). The aim of this study was to determine phenotypic changes that occur in basal-like tumors when IGF1R signaling is reduced. Transcriptomic analysis identified previously unknown cell subpopulations and alterations in gene expression that resulted from inhibition of the IGF1R in a mouse model of basal-like breast cancer. These outcomes can be used as biomarkers to enable new therapeutic approaches in patients with basal-like breast cancer.","dates":{"publication":"2026/05/28"},"accession":"GSE325555","cross_references":{"GSM":["GSM9608413","GSM9608406","GSM9608407","GSM9608408","GSM9608409","GSM9608410","GSM9608411","GSM9608412"],"GPL":["34328"],"GSE":["325555"],"taxon":["Mus musculus"]}}