{"database":"GEO","file_versions":[{"headers":{"Content-Type":["application/json"]},"body":{"files":{"Other":["ftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE325nnn/GSE325715/"]},"type":"primary"},"statusCode":"OK","statusCodeValue":200}],"scores":null,"additional":{"omics_type":["Transcriptomics"],"species":["Homo sapiens"],"gds_type":["Expression profiling by high throughput sequencing"],"full_dataset_link":["https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE325715"],"repository":["GEO"],"entry_type":["GSE"],"additional_accession":[]},"is_claimable":false,"name":"Gene expression in patients with pulmonary hypertension due to valve heart disease","description":"To delve deeper into the molecular mechanisms underlying pulmonary hypertension secondary to left heart disease (PH-LHD), an essential step toward developing a comprehensive classification, reliable biomarkers and targeted therapies. In this study, we analyzed the whole transcriptome (mRNA) of a unique cohort of patients with persistent PH due to valvular heart disease (PH-VHD) to identify biological pathways associated with disease prognosis. The analysis was performed using the well-characterized SIOVAC (Sildenafil for Improving Outcomes after Valvular Correction) clinical trial cohort. We included 116 patients with demonstrated PH-LHD after valvular correction, and 30 VHD patients with no or mild PH (Control).","dates":{"publication":"2026/03/26"},"accession":"GSE325715","cross_references":{"GSM":["GSM9611155","GSM9611154","GSM9611153","GSM9611152","GSM9611159","GSM9611158","GSM9611157","GSM9611156","GSM9611151","GSM9611150","GSM9611149","GSM9611144","GSM9611143","GSM9611142","GSM9611141","GSM9611148","GSM9611147","GSM9611146","GSM9611145","GSM9611140","GSM9611139","GSM9611138","GSM9611133","GSM9611132","GSM9611099","GSM9611098","GSM9611131","GSM9611097","GSM9611130","GSM9611137","GSM9611136","GSM9611135","GSM9611134","GSM9611092","GSM9611091","GSM9611090","GSM9611096","GSM9611095","GSM9611094","GSM9611093","GSM9611129","GSM9611128","GSM9611127","GSM9611089","GSM9611122","GSM9611121","GSM9611088","GSM9611120","GSM9611087","GSM9611086","GSM9611126","GSM9611125","GSM9611124","GSM9611123","GSM9611081","GSM9611080","GSM9611085","GSM9611084","GSM9611083","GSM9611082","GSM9611119","GSM9611118","GSM9611117","GSM9611116","GSM9611078","GSM9611199","GSM9611111","GSM9611077","GSM9611198","GSM9611110","GSM9611197","GSM9611076","GSM9611075","GSM9611196","GSM9611115","GSM9611114","GSM9611113","GSM9611112","GSM9611079","GSM9611070","GSM9611191","GSM9611190","GSM9611074","GSM9611195","GSM9611073","GSM9611194","GSM9611072","GSM9611193","GSM9611192","GSM9611071","GSM9611108","GSM9611107","GSM9611106","GSM9611105","GSM9611109","GSM9611100","GSM9611067","GSM9611188","GSM9611066","GSM9611187","GSM9611186","GSM9611185","GSM9611104","GSM9611103","GSM9611069","GSM9611102","GSM9611189","GSM9611101","GSM9611068","GSM9611180","GSM9611184","GSM9611183","GSM9611182","GSM9611181","GSM9611177","GSM9611210","GSM9611176","GSM9611175","GSM9611174","GSM9611179","GSM9611178","GSM9611211","GSM9611173","GSM9611172","GSM9611171","GSM9611170","GSM9611207","GSM9611206","GSM9611205","GSM9611204","GSM9611209","GSM9611208","GSM9611166","GSM9611165","GSM9611164","GSM9611163","GSM9611203","GSM9611169","GSM9611202","GSM9611201","GSM9611168","GSM9611200","GSM9611167","GSM9611162","GSM9611161","GSM9611160"],"GPL":["24676"],"GSE":["325715"],"taxon":["Homo sapiens"]}}