GEOapplication/xmlftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE325nnn/GSE325715/primaryOK200TranscriptomicsHomo sapiensExpression profiling by high throughput sequencinghttps://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE325715GEOGSEfalseGene expression in patients with pulmonary hypertension due to valve heart diseaseTo delve deeper into the molecular mechanisms underlying pulmonary hypertension secondary to left heart disease (PH-LHD), an essential step toward developing a comprehensive classification, reliable biomarkers and targeted therapies. In this study, we analyzed the whole transcriptome (mRNA) of a unique cohort of patients with persistent PH due to valvular heart disease (PH-VHD) to identify biological pathways associated with disease prognosis. The analysis was performed using the well-characterized SIOVAC (Sildenafil for Improving Outcomes after Valvular Correction) clinical trial cohort. We included 116 patients with demonstrated PH-LHD after valvular correction, and 30 VHD patients with no or mild PH (Control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 sapiens