{"database":"GEO","file_versions":[{"headers":{"Content-Type":["application/json"]},"body":{"files":{"Other":["ftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE325nnn/GSE325806/"]},"type":"primary"},"statusCode":"OK","statusCodeValue":200}],"scores":null,"additional":{"omics_type":["Transcriptomics"],"species":["Schmidtea mediterranea"],"gds_type":["Expression profiling by high throughput sequencing"],"full_dataset_link":["https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE325806"],"repository":["GEO"],"entry_type":["GSE"],"additional_accession":[]},"is_claimable":false,"name":"The stability of m6A-marked transcripts is linked to cell identity in planarians [MTC KD]","description":"Using Nanopore dRNA-Seq, we generated a high-confidence atlas of ~72,200 m6A sites (minimal methylation rate of 15% in at least two replicates) across the planarian transcriptome. We identified planarian m6A sites to be installed in a DRAYW context and to be highly enriched near stop codons. Upon depletion of METTL14 – a core component of the methyltransferase complex – we observed a significant reduction of m6A levels by 73.2%, as well as significant gene expression changes in 1059 genes. Loss of m6A resulted in up- as well as downregulation of genes, but cell type markers were found to be specifically represented in both gene classes.","dates":{"publication":"2026/08/18"},"accession":"GSE325806","cross_references":{"GSM":["GSM9613716","GSM9613717","GSM9613718","GSM9613719","GSM9613712","GSM9613713","GSM9613714","GSM9613715","GSM9613720"],"GPL":["36736"],"GSE":["325806"],"taxon":["Schmidtea mediterranea"],"PMID":["[42770330]"]}}