{"database":"GEO","file_versions":[{"headers":{"Content-Type":["application/json"]},"body":{"files":{"Other":["ftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE326nnn/GSE326229/"]},"type":"primary"},"statusCode":"OK","statusCodeValue":200}],"scores":null,"additional":{"omics_type":["Transcriptomics"],"species":["Mus musculus"],"gds_type":["Expression profiling by high throughput sequencing"],"full_dataset_link":["https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE326229"],"repository":["GEO"],"entry_type":["GSE"],"additional_accession":[]},"is_claimable":false,"name":"Transcriptomic effects of intermittent parathyroid hormone treatment on Sox9-lineage osteoprogenitors","description":"We employed 10X Genomics single cell RNA-sequencing to study the bone anabolic effects of intermittent parathyroid hormone treatment (iPTH) on growth-associated progenitors. These osteoblast progenitors, marked by the expression of the transcription factor SRY-box transcription factor 9 (Sox9), reside in the growth plate and perichondrium that respond to iPTH in early postnatal mice. Whether these cells respond in adult mice is unknown. Using lineage tracing approach with Sox9-CreERT2 crossed with Ai9 tdTomato reporter mice, we traced Sox9-expressing cells and their descendants following 10 days of vehicle or iPTH treatment. This study represents a single cell atlas of Sox9-lineage cells following 10 days of iPTH treatment.","dates":{"publication":"2026/09/20"},"accession":"GSE326229","cross_references":{"GSM":["GSM9625583","GSM9625582","GSM9625581","GSM9625580","GSM9625576","GSM9625587","GSM9625586","GSM9625575","GSM9625585","GSM9625584","GSM9625579","GSM9625578","GSM9625588","GSM9625577"],"GPL":["30172"],"GSE":["326229"],"taxon":["Mus musculus"]}}