GEOapplication/xmlftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE326nnn/GSE326229/primaryOK200TranscriptomicsMus musculusExpression profiling by high throughput sequencinghttps://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE326229GEOGSEfalseTranscriptomic effects of intermittent parathyroid hormone treatment on Sox9-lineage osteoprogenitorsWe employed 10X Genomics single cell RNA-sequencing to study the bone anabolic effects of intermittent parathyroid hormone treatment (iPTH) on growth-associated progenitors. These osteoblast progenitors, marked by the expression of the transcription factor SRY-box transcription factor 9 (Sox9), reside in the growth plate and perichondrium that respond to iPTH in early postnatal mice. Whether these cells respond in adult mice is unknown. Using lineage tracing approach with Sox9-CreERT2 crossed with Ai9 tdTomato reporter mice, we traced Sox9-expressing cells and their descendants following 10 days of vehicle or iPTH treatment. This study represents a single cell atlas of Sox9-lineage cells following 10 days of iPTH treatment.2026/09/20GSE326229GSM9625583GSM9625582GSM9625581GSM9625580GSM9625587GSM9625576GSM9625586GSM9625575GSM9625585GSM9625584GSM9625579GSM9625578GSM9625588GSM962557730172326229Mus musculus