GEOapplication/xmlftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE326nnn/GSE326327/primaryOK200TranscriptomicsMus musculusExpression profiling by arrayhttps://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE326327GEOGSEfalseNanoString nCounter Mouse PanCancer Immune Profiling of CT26 tumors following chronic in vitro PMS2 inhibition and in vivo anti-PD-1 treatmentNanoString nCounter immune profiling revealed that PMS2 inhibitor NP1867-pretreated tumours mounted an enhanced immune response to anti-PD-1 therapy, characterized by increased infiltration of lymphocytes, including T cells and cytotoxic populations, together with enrichment of multiple immune-related pathways. These included adaptive immune responses, antigen processing and presentation, MHC signaling, and interferon pathways, indicating that NP1867 pretreatment primes tumors for improved immunological responsiveness to PD-1 blockade.2026/04/21GSE326327GSM9629376GSM9629387GSM9629375GSM9629386GSM9629378GSM9629389GSM9629367GSM9629388GSM9629377GSM9629372GSM9629383GSM9629382GSM9629371GSM9629385GSM9629374GSM9629373GSM9629384GSM9629390GSM9629381GSM9629370GSM9629380GSM9629369GSM9629379GSM962936825652326327Mus musculus