{"database":"GEO","file_versions":[{"headers":{"Content-Type":["application/json"]},"body":{"files":{"Other":["ftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE326nnn/GSE326369/"]},"type":"primary"},"statusCode":"OK","statusCodeValue":200}],"scores":null,"additional":{"omics_type":["Transcriptomics"],"species":["Mus musculus"],"gds_type":["Expression profiling by high throughput sequencing"],"full_dataset_link":["https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE326369"],"repository":["GEO"],"entry_type":["GSE"],"additional_accession":[]},"is_claimable":false,"name":"ONX-0914 Ameliorates Hepatic Steatosis in MASLD by Stabilizing HDAC2 and Inhibiting SREBP1 Acetylation via PSMB8 Inhibition","description":"To investigate the mechanism by which ONX‑0914 ameliorates MASLD, HFD‑fed mice were randomized to receive the selective PSMB8 inhibitor ONX‑0914 (10 mg/kg in 10% captisol, s.c., every other day) or vehicle control for an additional 6 weeks while remaining on the HFD. At the experimental endpoint, liver tissues were collected for RNA sequencing.","dates":{"publication":"2026/04/02"},"accession":"GSE326369","cross_references":{"GSM":["GSM9629950","GSM9629949","GSM9629948","GSM9629945","GSM9629947","GSM9629946"],"GPL":["24247"],"GSE":["326369"],"taxon":["Mus musculus"]}}