{"database":"GEO","file_versions":[{"headers":{"Content-Type":["application/json"]},"body":{"files":{"Other":["ftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE326nnn/GSE326505/"]},"type":"primary"},"statusCode":"OK","statusCodeValue":200}],"scores":null,"additional":{"omics_type":["Transcriptomics"],"species":["Schizosaccharomyces pombe"],"gds_type":["Expression profiling by high throughput sequencing"],"full_dataset_link":["https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE326505"],"repository":["GEO"],"entry_type":["GSE"],"additional_accession":[]},"is_claimable":false,"name":"Differential gene expression drives cell-cycle-dependent transition from monopolar to bipolar growth in fission yeast","description":"In S. pombe, cells transition from monopolar to bipolar growth in a cell cycle-dependent manner. To investigate this, we performed RNA-seq analysis of the cell-cycle mutant cdc10-129 to identify distinct gene expression patterns in G1 versus G2 phase. Our analysis identified upregulation of the pheromone- and stress-response pathways in G1/S-arrested cells and cell wall organization genes in G2 cells. Protein interaction networks identified a spk1-byr2-ste11 stress-response hub in G1/S. in agreement we find that cells spk1 are precociously bipolar. We propose that pheromone-response pathways block bipolarity until nutrient-rich conditions downregulate these pathways, enabling cell cycle progression and bipolar transition.","dates":{"publication":"2026/03/31"},"accession":"GSE326505","cross_references":{"GSM":["GSM9632885","GSM9632896","GSM9632897","GSM9632886","GSM9632898","GSM9632887","GSM9632888","GSM9632899","GSM9632900","GSM9632889","GSM9632901","GSM9632890","GSM9632891","GSM9632892","GSM9632893","GSM9632894","GSM9632895","GSM9632884"],"GPL":["28961"],"GSE":["326505"],"taxon":["Schizosaccharomyces pombe"]}}