{"database":"GEO","file_versions":[{"headers":{"Content-Type":["application/json"]},"body":{"files":{"Other":["ftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE326nnn/GSE326580/"]},"type":"primary"},"statusCode":"OK","statusCodeValue":200}],"scores":null,"additional":{"omics_type":["Transcriptomics"],"species":["Rattus norvegicus"],"gds_type":["Expression profiling by high throughput sequencing"],"full_dataset_link":["https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE326580"],"repository":["GEO"],"entry_type":["GSE"],"additional_accession":[]},"is_claimable":false,"name":"A Biodegradable Piezoelectric Vertebral Implant for Programmable Electro-neuromodulation in Spinal Cord Injury","description":"Spinal cord stimulation is a promising strategy for functional recovery after spinal cord injury (SCI), but conventional electronic implants pose surgical and long-term risks. Here, we report a biodegradable piezoelectric cryogel (Piezo Gel) that enables programmable electro-neuromodulation without implanted electronics. Mimicking spinal biomechanics, Piezo Gel converts physiological movement into localized endogenous electric fields, while externally applied ultrasound (US) amplifies its electrical output, enabling on-demand in situ programming. In a rat model of acute severe SCI, US-activated Piezo Gel significantly enhanced locomotor recovery, improved Basso–Beattie–Bresnahan (BBB) scores, and promoted bladder functional remodeling. In a mild contusion model, we further implemented a phase-adaptive neuromodulation strategy, shifting from US-driven stimulation during acute immobility to movement-driven stimulation during subacute rehabilitation, aligning with the evolving spinal microenvironment. This sequential programming resulted in substantial restoration of coordinated gait. Together, this work establishes an electronic-free, programmable electro-neuromodulation paradigm that integrates US and physiological motion, offering a clinically translatable approach for SCI repair.","dates":{"publication":"2026/06/21"},"accession":"GSE326580","cross_references":{"GSM":["GSM9634914","GSM9634915","GSM9634916","GSM9634917","GSM9634918","GSM9634919"],"GPL":["25947"],"GSE":["326580"],"taxon":["Rattus norvegicus"]}}