GEOapplication/xmlftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE326nnn/GSE326580/primary200OKTranscriptomicsRattus norvegicusExpression profiling by high throughput sequencinghttps://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE326580GEOGSEfalseA Biodegradable Piezoelectric Vertebral Implant for Programmable Electro-neuromodulation in Spinal Cord InjurySpinal cord stimulation is a promising strategy for functional recovery after spinal cord injury (SCI), but conventional electronic implants pose surgical and long-term risks. Here, we report a biodegradable piezoelectric cryogel (Piezo Gel) that enables programmable electro-neuromodulation without implanted electronics. Mimicking spinal biomechanics, Piezo Gel converts physiological movement into localized endogenous electric fields, while externally applied ultrasound (US) amplifies its electrical output, enabling on-demand in situ programming. In a rat model of acute severe SCI, US-activated Piezo Gel significantly enhanced locomotor recovery, improved Basso–Beattie–Bresnahan (BBB) scores, and promoted bladder functional remodeling. In a mild contusion model, we further implemented a phase-adaptive neuromodulation strategy, shifting from US-driven stimulation during acute immobility to movement-driven stimulation during subacute rehabilitation, aligning with the evolving spinal microenvironment. This sequential programming resulted in substantial restoration of coordinated gait. Together, this work establishes an electronic-free, programmable electro-neuromodulation paradigm that integrates US and physiological motion, offering a clinically translatable approach for SCI repair.2026/06/21GSE326580GSM9634914GSM9634915GSM9634916GSM9634917GSM9634918GSM963491925947326580Rattus norvegicus