GEOTranscriptomicsMus musculusExpression profiling by high throughput sequencinghttps://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE326714GEOGSEfalsePeripheral serotonin regulates epidermal differentiation and dermal homeostasisSerotonin is a neurotransmitter with key peripheral functions including regulation of vascular tone, immune responses and tissue repair. It has been shown that it is expressed in skin but its role in skin homeostasis remains unclear. We conducted transcriptomic analyses to elucidate the effects of serotonin deficiency on epidermal and dermal compartments using tryptophan hydroxylase 1 knockout mice. Our results revealed that peripheral 5-HT plays a role in epidermal differentiation, barrier integrity and homeostasis of the dermal compartment.2026/04/10GSE326714GSM9637529GSM9637527GSM9637528GSM9637532GSM9637533GSM9637530GSM9637531GSM963753430172326714Mus musculus