GEOapplication/xmlftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE326nnn/GSE326716/primaryOK200TranscriptomicsRattus norvegicusExpression profiling by high throughput sequencinghttps://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE326716GEOGSEfalseAβ suppresses oligodendrocyte differentiation in vivo or vitro via inflammatory activation and cytoskeletal contraction [RNA-seq2]Aβ disrupts oligodendrocyte lineage cells through a dual mechanism inflammatory activation and cytoskeletal compromise leading to maturation blockade and hypomyelination independent of axonal damage. These findings position oligodendrocyte dysfunction as a key component of AD white matter pathology and identify potential therapeutic targets.2026/04/06GSE326716GSM9637541GSM963754231008326716Rattus norvegicus