GEOapplication/xmlftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE326nnn/GSE326774/primary200OKTranscriptomicsHomo sapiensExpression profiling by high throughput sequencinghttps://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE326774GEOGSEfalseSNHG29 knockdown by CRISPRi and shRNA in M07e acute myeloid leukemia cellsThe long non-coding RNA SNHG29 has been identified as a candidate essential gene in acute myeloid leukemia (AML) through a genome-wide CRISPRi depletion screen. To characterize the transcriptomic consequences of SNHG29 loss, we performed RNA-seq in M07e AML cells following SNHG29 knockdown using two independent methods: CRISPRi (two sgRNAs targeting the SNHG29 promoter, with Luciferase-targeting sgRNA as control) and shRNA (two shRNAs targeting SNHG29, with scrambled shRNA as control). Three biological replicates were generated per condition. Differential expression analysis was performed using DESeq2.2026/06/30GSE326774GSM9639029GSM9639028GSM9639027GSM9639026GSM9639037GSM9639032GSM9639031GSM9639030GSM9639036GSM9639025GSM9639024GSM9639035GSM9639023GSM9639034GSM963903324676326774Homo sapiens