{"database":"GEO","file_versions":[],"scores":null,"additional":{"omics_type":["Transcriptomics"],"species":["Mus musculus"],"gds_type":["Expression profiling by array"],"full_dataset_link":["https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE326825"],"repository":["GEO"],"entry_type":["GSE"],"additional_accession":[]},"is_claimable":false,"name":"Stem cell-derived exosomes inhibit the inflammatory response of microglia in neuropathic pain through m6A modification mechanisms","description":"Activated microglia-induced neuroinflammation is a critical pathological basis for the exacerbation of neuropathic pain. In our in vitro experiments, we found that exosomes derived from human umbilical cord mesenchymal stem cells exhibit a potent inhibitory effect on microglial inflammation, significantly downregulating the expression of lipopolysaccharide (LPS)-induced inflammatory factors such as interleukin-6 and interleukin-1, and suppressing microglial activation. However, the underlying molecular mechanism requires further investigation. m6A modification is considered one of the key molecular mechanisms regulating neuropathic pain, but whether stem cell-derived exosomes inhibit microglial inflammation through modulating m6A methylation remains to be further elucidated. Therefore, this study aims to investigate changes in m6A modification following exosome treatment, identify key m6A-modified genes and the regulatory enzymes involved, and use them as research targets to explore the molecular mechanism by which stem cell-derived exosomes alleviate neuropathic pain.","dates":{"publication":"2026/04/07"},"accession":"GSE326825","cross_references":{"GSM":["GSM9640968","GSM9640957","GSM9640967","GSM9640956","GSM9640959","GSM9640969","GSM9640958","GSM9640964","GSM9640963","GSM9640966","GSM9640965","GSM9640971","GSM9640960","GSM9640970","GSM9640973","GSM9640962","GSM9640972","GSM9640961"],"GPL":["25915"],"GSE":["326825"],"taxon":["Mus musculus"]}}