GEOTranscriptomicsMus musculusExpression profiling by arrayhttps://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE326825GEOGSEfalseStem cell-derived exosomes inhibit the inflammatory response of microglia in neuropathic pain through m6A modification mechanismsActivated microglia-induced neuroinflammation is a critical pathological basis for the exacerbation of neuropathic pain. In our in vitro experiments, we found that exosomes derived from human umbilical cord mesenchymal stem cells exhibit a potent inhibitory effect on microglial inflammation, significantly downregulating the expression of lipopolysaccharide (LPS)-induced inflammatory factors such as interleukin-6 and interleukin-1, and suppressing microglial activation. However, the underlying molecular mechanism requires further investigation. m6A modification is considered one of the key molecular mechanisms regulating neuropathic pain, but whether stem cell-derived exosomes inhibit microglial inflammation through modulating m6A methylation remains to be further elucidated. Therefore, this study aims to investigate changes in m6A modification following exosome treatment, identify key m6A-modified genes and the regulatory enzymes involved, and use them as research targets to explore the molecular mechanism by which stem cell-derived exosomes alleviate neuropathic pain.2026/04/07GSE326825GSM9640968GSM9640957GSM9640967GSM9640956GSM9640959GSM9640969GSM9640958GSM9640964GSM9640963GSM9640966GSM9640965GSM9640971GSM9640960GSM9640970GSM9640973GSM9640962GSM9640972GSM964096125915326825Mus musculus