{"database":"GEO","file_versions":[{"headers":{"Content-Type":["application/json"]},"body":{"files":{"Other":["ftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE326nnn/GSE326830/"]},"type":"primary"},"statusCode":"OK","statusCodeValue":200}],"scores":null,"additional":{"omics_type":["Transcriptomics"],"species":["Mus musculus"],"gds_type":["Expression profiling by high throughput sequencing"],"full_dataset_link":["https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE326830"],"repository":["GEO"],"entry_type":["GSE"],"additional_accession":[]},"is_claimable":false,"name":"Integrative transcriptomic analysis reveals Cytip as a novel pro-inflammatory factor which interacting with Lrrfip2 in microglia following","description":"In this study, we sought to elucidate the transcriptional landscape of microglia during the acute phase of cerebral I/R injury. By integrating transcriptomic data from an in vivo mouse model of middle cerebral artery occlusion/reperfusion (MCAO/R), with in vitro bulk RNA sequencing of Bv2 microglia subjected to oxygen-glucose deprivation/reperfusion (OGD/R), we identified Cytip (Cytohesin Interacting Protein) as significantly upregulated. Our results demonstrated that CYTIP expression peaked 24 h post-reperfusion and its knockdown markedly attenuated neuroinflammation.","dates":{"publication":"2026/07/14"},"accession":"GSE326830","cross_references":{"GSM":["GSM9641030","GSM9641029","GSM9641026","GSM9641025","GSM9641028","GSM9641027"],"GPL":["24247"],"GSE":["326830"],"taxon":["Mus musculus"]}}