GEOapplication/xmlftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE326nnn/GSE326856/suppl/filelist.txtftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE326nnn/GSE326856/suppl/GSE326856_RAW.tarftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE326nnn/GSE326856/primaryOK200TranscriptomicsRattus norvegicusExpression profiling by high throughput sequencinghttps://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE326856GEOGSEfalseSingle-cell RNA-seq profiles of intestinal mucosa in IBS-D rats to explore the mechanism of immune barrier regulation in pathogenesisWe have employed a single cell sequencing approach using 10x Genomics scRNAseq to study isolated endothelial cells, immune cells and stromal cells from the intestinal mucosa of the control group and diarrhea-predominant irritable bowel syndrome (IBS-D) rats. This study systematically deciphered the transcriptional landscape of the colonic mucosa in a rat model of IBS-D at single-cell resolution, revealing compositional shifts, transcriptional signatures, and potential regulatory networks among various cellular subpopulations, including epithelial, immune, and stromal cells.2026/07/08GSE326856GSM9641327GSM9641326GSM9641325GSM964132425947326856Rattus norvegicus