{"database":"GEO","file_versions":[{"headers":{"Content-Type":["application/json"]},"body":{"files":{"Other":["ftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE326nnn/GSE326887/"]},"type":"primary"},"statusCode":"OK","statusCodeValue":200}],"scores":null,"additional":{"omics_type":["Transcriptomics"],"species":["Mus musculus"],"gds_type":["Expression profiling by high throughput sequencing"],"full_dataset_link":["https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE326887"],"repository":["GEO"],"entry_type":["GSE"],"additional_accession":[]},"is_claimable":false,"name":"An Isoform-resolved Single-cell Atlas of the Murine Placenta: Gestational Dynamics During Syngeneic and Semi-allogeneic Pregnancy","description":"The maternal-fetal interface requires precise immune tolerance followed by coordinated inflammation at term. While single-cell studies defined placental cellular diversity, alternative splicing's contribution to immune regulation remains poorly understood. Here, we present an isoform-resolved single-cell transcriptomic resource of the murine placenta across mid- and late gestation in syngeneic and semi-allogeneic pregnancies. We identify global suppression of cytokine networks during mid-gestation semi-allogeneic pregnancies, accompanied by erythroid populations co-expressing immune programs. Isoform-level analysis reveals the coordinated generation of alternatively spliced cytokine receptor variants, including soluble decoys and intracellular traps, lacking necessary signaling domains. These variants co-express with canonical receptors, decoupling ligand binding from downstream signal transduction to fine-tune immune responses. At term, this landscape shifts to coordinated pro-inflammatory signaling. This interactive dataset provides a systems-level framework for understanding how post-transcriptional mechanisms shape immune adaptation during murine pregnancy.","dates":{"publication":"2026/04/15"},"accession":"GSE326887","cross_references":{"GSM":["GSM9642100","GSM9642099","GSM9642096","GSM9642098","GSM9642097"],"GPL":["34328"],"GSE":["326887"],"taxon":["Mus musculus"]}}