GEOapplication/xmlftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE326nnn/GSE326942/primaryOK200OtherMus musculusOtherhttps://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE326942GEOGSEfalseSpatial transcriptomics links hippocampal synaptic remodeling to microglial phagocytosis in synucleinopathySynucleinopathies, including Parkinson’s disease and Lewy body dementia, show region-specific vulnerability across the brain, but the molecular basis of selective regional involvement remains incompletely understood. We performed spatial transcriptomic profiling of brain sections from 6-month-old G2-3 alpha-synuclein transgenic mice and wild-type littermates using the 10x Genomics Visium Spatial Gene Expression platform to characterize region-specific transcriptional alterations associated with alpha-synuclein pathology. This dataset provides a resource for investigating spatially resolved molecular changes in the synucleinopathy mouse brain.2026/04/08GSE326942GSM9643955GSM964395424247326942Mus musculus