{"database":"GEO","file_versions":[{"headers":{"Content-Type":["application/json"]},"body":{"files":{"Other":["ftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE327nnn/GSE327101/"]},"type":"primary"},"statusCodeValue":200,"statusCode":"OK"}],"scores":null,"additional":{"omics_type":["Transcriptomics"],"species":["Homo sapiens"],"gds_type":[" Genome binding/occupancy profiling by high throughput sequencing","Expression profiling by high throughput sequencing"],"full_dataset_link":["https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE327101"],"repository":["GEO"],"entry_type":["GSE"],"additional_accession":[]},"is_claimable":false,"name":"Single-Cell Multimodal Atlas Reveals Regulatory Programs in the Human Brain","description":"Directly measuring chromatin states alongside transcription is essential for understanding how cell-type-specific regulatory programs are established and maintained in the adult human brain. We present a large-scale single-cell multimodal atlas generated by jointly profiling transcriptome with active (H3K27ac) and repressive (H3K27me3) histone modifications across 18 brain regions. We profile >750,000 nuclei spanning 160 cell types and integrate these data with chromatin accessibility, DNA methylation, 3D genome architecture, and spatial transcriptome. This framework annotates >500,000 regulatory elements and resolves cell-type-specific chromatin states. We link enhancers to target genes, infer gene regulatory networks, and classify chromatin interactions, revealing neuron-enriched long-range Polycomb repression of developmental genes. Integrating these maps with GWAS data and sequence-based model prioritizes noncoding variants, effector genes, and vulnerable cell types for neuropsychiatric disorders. Finally, cross-species comparisons show conserved activation but more divergent repression. Together, this study provides a functional reference for interpreting noncoding variants, epigenetic memory, and brain organization.","dates":{"publication":"2026/06/26"},"accession":"GSE327101","cross_references":{"GSM":["GSM9660328","GSM9660327","GSM9660329","GSM9648320","GSM9648329","GSM9660331","GSM9648321","GSM9648322","GSM9660330","GSM9648323","GSM9660333","GSM9648324","GSM9660332","GSM9660335","GSM9648325","GSM9660334","GSM9648326","GSM9660337","GSM9648327","GSM9660336","GSM9648328","GSM9660339","GSM9660338","GSM9648318","GSM9648319","GSM9660340","GSM9648310","GSM9648311","GSM9660341","GSM9648312","GSM9648313","GSM9648314","GSM9648315","GSM9648316","GSM9648317","GSM9660306","GSM9660305","GSM9660308","GSM9660307","GSM9648340","GSM9660309","GSM9648341","GSM9648342","GSM9648343","GSM9648344","GSM9660311","GSM9648345","GSM9648346","GSM9660310","GSM9648347","GSM9660313","GSM9660312","GSM9648348","GSM9648349","GSM9660315","GSM9660314","GSM9660317","GSM9660316","GSM9660319","GSM9660318","GSM9648330","GSM9648331","GSM9648332","GSM9660320","GSM9648333","GSM9648334","GSM9660322","GSM9648335","GSM9660321","GSM9648336","GSM9660324","GSM9648337","GSM9660323","GSM9660326","GSM9648338","GSM9660325","GSM9648339","GSM9660300","GSM9660302","GSM9660301","GSM9660304","GSM9660303","GSM9648307","GSM9648308","GSM9648309","GSM9648300","GSM9648301","GSM9648302","GSM9648303","GSM9648304","GSM9648305","GSM9648306","GSM9660290","GSM9660292","GSM9660291","GSM9660294","GSM9660293","GSM9660296","GSM9660295","GSM9660298","GSM9660297","GSM9660299","GSM9648390","GSM9648391","GSM9648392","GSM9648393","GSM9648394","GSM9648395","GSM9648396","GSM9648397","GSM9648398","GSM9648399","GSM9660270","GSM9660272","GSM9660271","GSM9660274","GSM9660273","GSM9660276","GSM9660275","GSM9660278","GSM9660277","GSM9660279","GSM9648291","GSM9648292","GSM9648293","GSM9648294","GSM9648295","GSM9648296","GSM9648297","GSM9648298","GSM9648290","GSM9660281","GSM9660280","GSM9660283","GSM9660282","GSM9660285","GSM9660284","GSM9648299","GSM9660287","GSM9660286","GSM9660289","GSM9660288","GSM9648360","GSM9648361","GSM9648362","GSM9648363","GSM9648364","GSM9660250","GSM9660252","GSM9660251","GSM9660254","GSM9648365","GSM9648366","GSM9660253","GSM9660256","GSM9648367","GSM9660255","GSM9648368","GSM9648369","GSM9660258","GSM9660257","GSM9660259","GSM9648350","GSM9648351","GSM9648352","GSM9648353","GSM9660261","GSM9660260","GSM9660263","GSM9660262","GSM9648354","GSM9660265","GSM9648355","GSM9660264","GSM9648356","GSM9660267","GSM9648357","GSM9660266","GSM9648358","GSM9660269","GSM9660268","GSM9648359","GSM9648380","GSM9648381","GSM9648382","GSM9648383","GSM9648384","GSM9648385","GSM9648386","GSM9660232","GSM9648387","GSM9648388","GSM9660234","GSM9648389","GSM9660233","GSM9660236","GSM9660235","GSM9660238","GSM9660237","GSM9660239","GSM9648370","GSM9648371","GSM9648372","GSM9648373","GSM9648374","GSM9648375","GSM9660241","GSM9660240","GSM9648376","GSM9660243","GSM9648377","GSM9660242","GSM9660245","GSM9648378","GSM9648379","GSM9660244","GSM9660247","GSM9660246","GSM9660249","GSM9660248"],"GPL":["34281"],"GSE":["327101"],"taxon":["Homo sapiens"],"PMID":["[41676679]"]}}