{"database":"GEO","file_versions":[],"scores":null,"additional":{"omics_type":["Transcriptomics"],"species":["Mus musculus"],"gds_type":["Expression profiling by high throughput sequencing"],"full_dataset_link":["https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE327115"],"repository":["GEO"],"entry_type":["GSE"],"additional_accession":[]},"is_claimable":false,"name":"Treg-Derived IFN-γ Supports the Differentiation of Th1-Treg in tumor immunity and autoimmunity","description":"Tregs in tumors are functionally heterogeneous, and Th1-Tregs represent a highly suppressive subset. This study identifies Tregs themselves as a source of IFN-γ, which promotes Th1-Treg differentiation. Treg-derived IFN-γ acts in an autocrine manner to sustain T-bet expression and the Th1-Treg phenotype, while PF4 from Arg1(+) TAMs further amplifies this pathway by inducing Ifng expression in Tregs. Conditional deletion of Ifng in Foxp3(+) cells impaired Th1-Treg differentiation in both tumors and spleen, and a similar mechanism was observed in EAE. Overall, Treg-derived IFN-γ forms a positive feedback loop with other IFN-γ sources and TAM-derived PF4, driving the maintenance and accumulation of Th1-Tregs and reinforcing immunosuppression.","dates":{"publication":"2026/06/03"},"accession":"GSE327115","cross_references":{"GSM":["GSM9648570","GSM9648571","GSM9648572","GSM9648573","GSM9648574","GSM9648575","GSM9648576","GSM9648577","GSM9648568","GSM9648569"],"GPL":["24247"],"GSE":["327115"],"taxon":["Mus musculus"],"PMID":["[42206029]"]}}