{"database":"GEO","file_versions":[{"headers":{"Content-Type":["application/json"]},"body":{"files":{"Other":["ftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE327nnn/GSE327152/"]},"type":"primary"},"statusCode":"OK","statusCodeValue":200}],"scores":null,"additional":{"omics_type":["Transcriptomics"],"species":["Mus musculus"],"gds_type":["Expression profiling by high throughput sequencing"],"full_dataset_link":["https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE327152"],"repository":["GEO"],"entry_type":["GSE"],"additional_accession":[]},"is_claimable":false,"name":"Cardiac tertiary immune niches drive immune activation in immune checkpoint inhibitor myocarditis","description":"Using integrated spatial and single-cell analyses in a pharmacological murine model, we identified regional infiltration of inflammatory myeloid cells and PD-1⁺CD8⁺ T cells in the heart that organize into fibroblast-rich immune structures, which we term Tertiary T Cell Niches (TTCNs). TTCNs serve as hubs for T cell activation, sharing features of tertiary lymphoid structures. Complementary TCR analyses revealed clonal expansion of cardiac T cells following ICI treatment. Together, these findings suggest that cardiac tertiary immune structures play a central role in activating and recruiting immune cells in ICI myocarditis and highlight pathways that could mitigate ICI cardiotoxicity.","dates":{"publication":"2026/04/06"},"accession":"GSE327152","cross_references":{"GSM":["GSM9649324"],"GPL":["34328"],"GSE":["327152"],"taxon":["Mus musculus"]}}