{"database":"GEO","file_versions":[],"scores":null,"additional":{"omics_type":["Transcriptomics"],"species":["Homo sapiens"],"gds_type":["Expression profiling by high throughput sequencing"],"full_dataset_link":["https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE327171"],"repository":["GEO"],"entry_type":["GSE"],"additional_accession":[]},"is_claimable":false,"name":"A High Dimensionality Approach Reveals Immunopathogenic Responses Driving Severe Pediatric Acute Respiratory Distress Syndrome","description":"Mechanisms underlying paediatric acute respiratory distress syndrome (PARDS) remain poorly understood, limiting advances in diagnosis and treatment. To address this gap, we adopted a high-dimensional multi-omics approach to better understand immune dysregulation in PARDS, aiming to identify distinct pathogenic pathways. We show that severe PARDS is marked by interferon-driven immune dysregulation, with pulmonary T cells and myeloid cells exhibiting strong interferon responses and suppressed IL-1 pathways, resulting in impaired immune cell function and reduced IL-1α/β levels.","dates":{"publication":"2026/05/12"},"accession":"GSE327171","cross_references":{"GSM":["GSM9650480","GSM9650462","GSM9650473","GSM9650472","GSM9650461","GSM9650471","GSM9650460","GSM9650470","GSM9650477","GSM9650466","GSM9650465","GSM9650476","GSM9650475","GSM9650464","GSM9650474","GSM9650463","GSM9650459","GSM9650469","GSM9650458","GSM9650468","GSM9650457","GSM9650479","GSM9650478","GSM9650467"],"GPL":["20301"],"GSE":["327171"],"taxon":["Homo sapiens"]}}