GEOapplication/xmlftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE327nnn/GSE327171/primaryOK200TranscriptomicsHomo sapiensExpression profiling by high throughput sequencinghttps://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE327171GEOGSEfalseA High Dimensionality Approach Reveals Immunopathogenic Responses Driving Severe Pediatric Acute Respiratory Distress SyndromeMechanisms underlying paediatric acute respiratory distress syndrome (PARDS) remain poorly understood, limiting advances in diagnosis and treatment. To address this gap, we adopted a high-dimensional multi-omics approach to better understand immune dysregulation in PARDS, aiming to identify distinct pathogenic pathways. We show that severe PARDS is marked by interferon-driven immune dysregulation, with pulmonary T cells and myeloid cells exhibiting strong interferon responses and suppressed IL-1 pathways, resulting in impaired immune cell function and reduced IL-1α/β levels.2026/05/12GSE327171GSM9650480GSM9650462GSM9650473GSM9650472GSM9650461GSM9650471GSM9650460GSM9650470GSM9650466GSM9650477GSM9650465GSM9650476GSM9650475GSM9650464GSM9650474GSM9650463GSM9650459GSM9650469GSM9650458GSM9650468GSM9650457GSM9650479GSM9650478GSM965046720301327171Homo sapiens