{"database":"GEO","file_versions":[{"headers":{"Content-Type":["application/json"]},"body":{"files":{"Other":["ftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE327nnn/GSE327176/"]},"type":"primary"},"statusCode":"OK","statusCodeValue":200}],"scores":null,"additional":{"omics_type":["Transcriptomics"],"species":["Mus musculus"],"gds_type":["Expression profiling by high throughput sequencing"],"full_dataset_link":["https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE327176"],"repository":["GEO"],"entry_type":["GSE"],"additional_accession":[]},"is_claimable":false,"name":"Single-cell transcriptomic profiling unveils tumor-mediated reprogramming of neutrophils and their unique vulnerability that inhibits metastasis","description":"We performed single cell RNA sequencing (scRNAseq) with the 10x Genomics platform to study how neutrophils are reprogrammed during breast tumorigenesis. Neutrophils acquire a pro-metastatic phenotype induced by signals eminating from the tumor. This comprehensive scRNAseq study assessed neutrophils from various tissues in naive and tumor-bearing MMTV-PyMT mice to uncover how neutrophils are transcriptionally modified. We found that neutrophils are reprogrammed similarly amongst tissues in tumor-bearing mice, and that G-CSF is the main driver of this.","dates":{"publication":"2026/07/17"},"accession":"GSE327176","cross_references":{"GSM":["GSM9650561","GSM9650560","GSM9650543","GSM9650565","GSM9650564","GSM9650563","GSM9650562","GSM9650547","GSM9650546","GSM9650567","GSM9650545","GSM9650566","GSM9650544","GSM9650559","GSM9650550","GSM9650554","GSM9650553","GSM9650552","GSM9650551","GSM9650558","GSM9650557","GSM9650556","GSM9650555","GSM9650549","GSM9650548"],"GPL":["24247"],"GSE":["327176"],"taxon":["Mus musculus"],"PMID":["[42455928]"]}}