GEOapplication/xmlftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE327nnn/GSE327176/primaryOK200TranscriptomicsMus musculusExpression profiling by high throughput sequencinghttps://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE327176GEOGSEfalseSingle-cell transcriptomic profiling unveils tumor-mediated reprogramming of neutrophils and their unique vulnerability that inhibits metastasisWe performed single cell RNA sequencing (scRNAseq) with the 10x Genomics platform to study how neutrophils are reprogrammed during breast tumorigenesis. Neutrophils acquire a pro-metastatic phenotype induced by signals eminating from the tumor. This comprehensive scRNAseq study assessed neutrophils from various tissues in naive and tumor-bearing MMTV-PyMT mice to uncover how neutrophils are transcriptionally modified. We found that neutrophils are reprogrammed similarly amongst tissues in tumor-bearing mice, and that G-CSF is the main driver of this.2026/07/17GSE327176GSM9650561GSM9650560GSM9650543GSM9650565GSM9650564GSM9650563GSM9650562GSM9650547GSM9650546GSM9650567GSM9650545GSM9650566GSM9650544GSM9650559GSM9650550GSM9650554GSM9650553GSM9650552GSM9650551GSM9650558GSM9650557GSM9650556GSM9650555GSM9650549GSM965054824247327176Mus musculus