GEOapplication/xmlftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE327nnn/GSE327216/primaryOK200GenomicsHomo sapiensNon-coding RNA profiling by arrayhttps://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE327216GEOGSEfalseCirculating miR-22 predicts TACE response and targets WEE1 in hepatocellular carcinomaTransarterial Chemoembolization (TACE) is the standard therapy for intermediate-stage liver cancer, yet high failure rates and a lack of early biomarkers remain significant challenges. Our study shows that circulating miR-22 levels increase significantly within 48 hours in TACE non-responders, providing a much faster alternative to traditional imaging for identifying treatment failure. Mechanistically, we identified the G2/M checkpoint kinase WEE1 as a direct functional target of miR-22. The miR-22/WEE1 axis has been identified as both a reliable predictor of outcomes and a potential target for personalized therapeutic interventions.2026/05/06GSE327216GSM9651393GSM9651392GSM9651391GSM9651390GSM9651397GSM9651386GSM9651396GSM9651395GSM9651394GSM9651400GSM9651389GSM9651399GSM9651388GSM9651398GSM965138715018327216Homo sapiens[42041589]