{"database":"GEO","file_versions":[{"headers":{"Content-Type":["application/json"]},"body":{"files":{"Other":["ftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE327nnn/GSE327306/"]},"type":"primary"},"statusCode":"OK","statusCodeValue":200}],"scores":null,"additional":{"omics_type":["Genomics"],"species":["Homo sapiens"],"gds_type":["Genome binding/occupancy profiling by high throughput sequencing"],"full_dataset_link":["https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE327306"],"repository":["GEO"],"entry_type":["GSE"],"additional_accession":[]},"is_claimable":false,"name":"DOT1L shapes ncPRC1-target gene repression to maintain cell identity of DLBCL [CUT&Tag]","description":"DOT1L inhibition leads to a loss of H2AK119ub1 in different GC B-DLBCL cell lines. To determine whether this loss is global or gene specific, performed H2AK119ub1 and H3K27me3 CUT&Tag in the Oci-Ly7 cell line following six days of treatment with DMSO or DOT1Li. As reference, we used a doxycycline-inducible knockdown of USP7 due to its role in ncPRC1-mediated deposition of H2AK119ub1 in Oci-Ly7 cells.","dates":{"publication":"2026/06/19"},"accession":"GSE327306","cross_references":{"GSM":["GSM9653198","GSM9653199","GSM9653200","GSM9653201","GSM9653194","GSM9653195","GSM9653196","GSM9653197","GSM9653191","GSM9653192","GSM9653193","GSM9653202"],"GPL":["18573"],"GSE":["327306"],"taxon":["Homo sapiens"]}}