GEOapplication/xmlftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE327nnn/GSE327306/primaryOK200GenomicsHomo sapiensGenome binding/occupancy profiling by high throughput sequencinghttps://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE327306GEOGSEfalseDOT1L shapes ncPRC1-target gene repression to maintain cell identity of DLBCL [CUT&Tag]DOT1L inhibition leads to a loss of H2AK119ub1 in different GC B-DLBCL cell lines. To determine whether this loss is global or gene specific, performed H2AK119ub1 and H3K27me3 CUT&Tag in the Oci-Ly7 cell line following six days of treatment with DMSO or DOT1Li. As reference, we used a doxycycline-inducible knockdown of USP7 due to its role in ncPRC1-mediated deposition of H2AK119ub1 in Oci-Ly7 cells.2026/06/19GSE327306GSM9653198GSM9653199GSM9653200GSM9653201GSM9653194GSM9653195GSM9653196GSM9653197GSM9653191GSM9653192GSM9653193GSM965320218573327306Homo sapiens