{"database":"GEO","file_versions":[{"headers":{"Content-Type":["application/json"]},"body":{"files":{"Other":["ftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE327nnn/GSE327530/"]},"type":"primary"},"statusCodeValue":200,"statusCode":"OK"}],"scores":null,"additional":{"omics_type":["Genomics"],"species":["Homo sapiens"],"gds_type":["Non-coding RNA profiling by high throughput sequencing"],"full_dataset_link":["https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE327530"],"repository":["GEO"],"entry_type":["GSE"],"additional_accession":[]},"is_claimable":false,"name":"Biomass Combustion Produces Hormone-like Pollutants: An Ignored Source [ncRNA-seq]","description":"Biomass burning, including household fuels and wildfires, affects billions globally, yet the unique health-related chemical components of PM2.5 emitted from these sources remain poorly understood. Here, we demonstrate that combustion of biomass—yak dung and pine—generates abundant hormone-like components within PM2.5, including natural, synthetic steroids and endocrine disruptors such as estradiol, testosterone enanthate and bisphenol A. Integrated network toxicology and whole-transcriptome sequencing reveal that these hormone compounds may exert distinct, fuel-specific respiratory toxicity by targeting critical genes (e.g., HIF1A or INHBA), functions (e.g., regulation of progesterone secretion or protein serine/threonine kinase activity) and pathways (e.g., vitamin digestion and absorption or RNA polymerase) via multi-level RNA regulation and mutagenic events. Our modelling estimates that mitigating this exposure could prevent ~66,000 premature deaths and yield economic benefits exceeding $11 billion annually. These findings uncover a previously unrecognized class of environmental hormonal pollutants generated by biomass combustion, redefine the health risks of air pollution, and provide a mechanistic foundation for advancing environmental justice and achieving Sustainable Development Goals in vulnerable populations worldwide.","dates":{"publication":"2026/04/30"},"accession":"GSE327530","cross_references":{"GSM":["GSM9660151","GSM9660150","GSM9660153","GSM9660152","GSM9660154","GSM9660146","GSM9660148","GSM9660147","GSM9660149"],"GPL":["18460"],"GSE":["327530"],"taxon":["Homo sapiens"]}}