{"database":"GEO","file_versions":[{"headers":{"Content-Type":["application/json"]},"body":{"files":{"Other":["ftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE327nnn/GSE327619/"]},"type":"primary"},"statusCode":"OK","statusCodeValue":200}],"scores":null,"additional":{"omics_type":["Transcriptomics"],"species":["Mus musculus"],"gds_type":["Expression profiling by high throughput sequencing"],"full_dataset_link":["https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE327619"],"repository":["GEO"],"entry_type":["GSE"],"additional_accession":[]},"is_claimable":false,"name":"Murine Endothelial Chromatin Remodeling Enzymes Modulate Plasmin Activity and Sterile Inflammation to Prevent Lethal Embryonic Liver Deterioration","description":"Transcriptional changes in liver sinusoidal endothelial cells (LSECs) from mutant mouse embryos lacking endothelial chromatin-remodeling enzymes need investigation. In this study, we compared the transcriptomes of CD146+ LSECs and the non-EC liver cells from control, Chd4fl/fl;Brg1fl/+;VE-cadherin-Cre+, Chd4fl/+;Brg1fl/fl;VE-cadherin-Cre+, and Chd4fl/fl;Brg1fl/fl;VE-cadherin-Cre+ mice at embryonic day 12.5. Our results show that inflammation-related gene expression is upregulated in endothelial mutants lacking Chd4 and returns to normal when both Chd4 and Brg1 are deleted.","dates":{"publication":"2026/05/12"},"accession":"GSE327619","cross_references":{"GSM":["GSM9662290","GSM9662293","GSM9662282","GSM9662294","GSM9662283","GSM9662291","GSM9662292","GSM9662281","GSM9662286","GSM9662297","GSM9662298","GSM9662287","GSM9662295","GSM9662284","GSM9662296","GSM9662285","GSM9662301","GSM9662302","GSM9662299","GSM9662288","GSM9662289","GSM9662300","GSM9662303","GSM9662304"],"GPL":["24247"],"GSE":["327619"],"taxon":["Mus musculus"]}}