GEOapplication/xmlftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE327nnn/GSE327619/primaryOK200TranscriptomicsMus musculusExpression profiling by high throughput sequencinghttps://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE327619GEOGSEfalseMurine Endothelial Chromatin Remodeling Enzymes Modulate Plasmin Activity and Sterile Inflammation to Prevent Lethal Embryonic Liver DeteriorationTranscriptional changes in liver sinusoidal endothelial cells (LSECs) from mutant mouse embryos lacking endothelial chromatin-remodeling enzymes need investigation. In this study, we compared the transcriptomes of CD146+ LSECs and the non-EC liver cells from control, Chd4fl/fl;Brg1fl/+;VE-cadherin-Cre+, Chd4fl/+;Brg1fl/fl;VE-cadherin-Cre+, and Chd4fl/fl;Brg1fl/fl;VE-cadherin-Cre+ mice at embryonic day 12.5. Our results show that inflammation-related gene expression is upregulated in endothelial mutants lacking Chd4 and returns to normal when both Chd4 and Brg1 are deleted.2026/05/12GSE327619GSM9662290GSM9662282GSM9662293GSM9662294GSM9662283GSM9662291GSM9662292GSM9662281GSM9662286GSM9662297GSM9662298GSM9662287GSM9662295GSM9662284GSM9662285GSM9662296GSM9662301GSM9662302GSM9662288GSM9662299GSM9662289GSM9662300GSM9662303GSM966230424247327619Mus musculus