{"database":"GEO","file_versions":[],"scores":null,"additional":{"omics_type":["Transcriptomics"],"species":["Mus musculus"],"gds_type":["Expression profiling by high throughput sequencing"],"full_dataset_link":["https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE327666"],"repository":["GEO"],"entry_type":["GSE"],"additional_accession":[]},"is_claimable":false,"name":"BPTF is essential for vaccine-induced germinal center B cell responses","description":"Germinal centers (GCs) are microanatomical structures in which antigen-specific B cells undergo proliferation, somatic hypermutation, and affinity-based competition to select high affinity clones that differentiate into memory B cells (MBCs) and plasma cells (PCs). B cell progression through the GC is tightly regulated and the molecular determinants that modulate GC B cell proliferation and survival are still under investigation. Here, we use a conditional deletion mouse model to demonstrate that bromodomain PHD finger transcription factor (BPTF), a subunit of the nucleosome remodeling factor (NURF) chromatin remodeling complex, is required for robust GC B cell responses following vaccination. In GC B cells, Bptf loss induces a stress-like transcriptional profile and a shift towards PC identity-defining transcriptional programing, although this does not lead to accumulation of functional PCs. Rather, we show that BPTF-deficient GC B cells are prone to cell death. Cumulatively, our data demonstrate that BPTF is necessary for GC B cell maintenance and robust antigen-specific B cell responses.","dates":{"publication":"2026/04/17"},"accession":"GSE327666","cross_references":{"GSM":["GSM9662925","GSM9662926","GSM9662923","GSM9662924","GSM9662929","GSM9662927","GSM9662928","GSM9662932","GSM9662933","GSM9662922","GSM9662930","GSM9662931"],"GPL":["34290"],"GSE":["327666"],"taxon":["Mus musculus"]}}