{"database":"GEO","file_versions":[{"headers":{"Content-Type":["application/json"]},"body":{"files":{"Other":["ftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE327nnn/GSE327753/"]},"type":"primary"},"statusCode":"OK","statusCodeValue":200}],"scores":null,"additional":{"omics_type":["Transcriptomics"],"species":["Mus musculus"],"gds_type":["Expression profiling by high throughput sequencing"],"full_dataset_link":["https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE327753"],"repository":["GEO"],"entry_type":["GSE"],"additional_accession":[]},"is_claimable":false,"name":"Immunological tolerance is maintained by self-reactive CD8 T cells","description":"CD8 T cells play a critical role in immune tolerance maintenance after immune activation. They have recently been reported to target activated CD4 T cells in an MHC-Ia–restricted manner. However, the specific peptides and the corresponding reactive CD8 TCRs responsible for this targeting process remain unknown. In this study, we identified the self-peptides on activated CD4 T cells, cloned the corresponding CD8 TCRs, and validated the in vitro and in vivo immunosuppressive function of CD8 T cells carrying these self-reactive TCRs. The therapeutic potential of peptide vaccination and self-reactive CD8 T cells was confirmed in a mouse model of experimental autoimmune encephalitis (EAE). This study consequently redefines the nature of CD8 regulatory T (Treg) cells as self-reactive CD8 T cells.","dates":{"publication":"2026/04/13"},"accession":"GSE327753","cross_references":{"GSM":["GSM9664993","GSM9664991","GSM9664996","GSM9664994","GSM9664989","GSM9664987"],"GPL":["24247"],"GSE":["327753"],"taxon":["Mus musculus"]}}