{"database":"GEO","file_versions":[{"headers":{"Content-Type":["application/json"]},"body":{"files":{"Other":["ftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE327nnn/GSE327756/"]},"type":"primary"},"statusCode":"OK","statusCodeValue":200}],"scores":null,"additional":{"omics_type":["Methylation profiling"],"species":["Mus musculus"],"gds_type":["Methylation profiling by high throughput sequencing"],"full_dataset_link":["https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE327756"],"repository":["GEO"],"entry_type":["GSE"],"additional_accession":[]},"is_claimable":false,"name":"TET2-mutant clonal hematopoiesis prevents T-cell exhaustion and suppresses cancer metastasis","description":"TET2-mutant clonal hematopoiesis (CH) is associated with reduced cancer metastasis in human cohorts. Whole genome bisulfite sequencing (WGBS) of PD-1+CD8+ tumor-infiltrating lymphocytes (TILs) sorted from liver metastatic tumors of Vav1CreTet2KO and Tet2fl/fl mice was performed to characterize genome-wide DNA methylation changes associated with TET2 loss in exhausted CD8+ T cells.","dates":{"publication":"2026/04/17"},"accession":"GSE327756","cross_references":{"GSM":["GSM9665473","GSM9665472","GSM9665471","GSM9665470","GSM9665469","GSM9665468"],"GPL":["34328"],"GSE":["327756"],"taxon":["Mus musculus"]}}