{"database":"GEO","file_versions":[{"headers":{"Content-Type":["application/json"]},"body":{"files":{"Other":["ftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE327nnn/GSE327889/"]},"type":"primary"},"statusCodeValue":200,"statusCode":"OK"}],"scores":null,"additional":{"omics_type":["Transcriptomics"],"species":["Homo sapiens"],"gds_type":["Expression profiling by array"],"full_dataset_link":["https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE327889"],"repository":["GEO"],"entry_type":["GSE"],"additional_accession":[]},"is_claimable":false,"name":"Molecular Rejection Signatures in Pancreas Transplant Biopsies","description":"This retrospective, single-center study included 124 pancreas allograft biopsies obtained between April 2019 and May 2025. Biopsies were analyzed using a kidney-derived Molecular Microscope® Diagnostic System (MMDx) classifier, and molecular classifications were compared with histology and related to pancreas graft survival. MMDx classified 93 biopsies (75%) as no rejection, 13 (10%) as subthreshold rejection, and 18 (15%) as rejection, whereas histology identified rejection in 65 of 112 biopsies (58%) and 25 (22%) as indeterminate cases. Concordance between histology and MMDx was low (Cohen’s κ = 0.14, p<0.001). Acute cellular histologic grading correlated strongly with multiple molecular scores, including interstitial inflammation (ρ=0.60, p=3.4×10⁻12), TCMR (ρ=0.55, p<3.2×10⁻10), acute kidney injury (ρ=0.48, p=7.4×10⁻8), and overall inflammation (ρ=0.46, p=4.4×10⁻7). Both subthreshold rejection (HR=4.41, 95% CI 1.29–15.1, p=0.018) and MMDx-defined rejection (HR=6.52, 95% CI 2.36–18.03, p=0.0003) were associated with significantly worse three-year graft survival compared to no rejection, whereas histologic classification showed no significant prognostic impact. Molecular assessment using a kidney-derived MMDx classifier provides complementary prognostic information beyond histology in pancreas transplantation.","dates":{"publication":"2026/06/30"},"accession":"GSE327889","cross_references":{"GSM":["GSM9667883","GSM9667884","GSM9667885","GSM9667886","GSM9667880","GSM9667881","GSM9667882","GSM9667803","GSM9667804","GSM9667805","GSM9667806","GSM9667887","GSM9667888","GSM9667800","GSM9667889","GSM9667801","GSM9667769","GSM9667802","GSM9667807","GSM9667808","GSM9667809","GSM9667773","GSM9667774","GSM9667775","GSM9667776","GSM9667890","GSM9667770","GSM9667891","GSM9667892","GSM9667771","GSM9667772","GSM9667814","GSM9667815","GSM9667816","GSM9667817","GSM9667810","GSM9667777","GSM9667778","GSM9667811","GSM9667812","GSM9667779","GSM9667813","GSM9667861","GSM9667862","GSM9667863","GSM9667864","GSM9667860","GSM9667869","GSM9667865","GSM9667866","GSM9667867","GSM9667868","GSM9667872","GSM9667873","GSM9667874","GSM9667875","GSM9667870","GSM9667871","GSM9667876","GSM9667877","GSM9667878","GSM9667879","GSM9667840","GSM9667841","GSM9667842","GSM9667847","GSM9667848","GSM9667849","GSM9667843","GSM9667844","GSM9667845","GSM9667846","GSM9667850","GSM9667851","GSM9667852","GSM9667853","GSM9667858","GSM9667859","GSM9667854","GSM9667855","GSM9667856","GSM9667857","GSM9667818","GSM9667819","GSM9667784","GSM9667785","GSM9667786","GSM9667787","GSM9667820","GSM9667780","GSM9667781","GSM9667782","GSM9667783","GSM9667825","GSM9667826","GSM9667827","GSM9667828","GSM9667821","GSM9667788","GSM9667789","GSM9667822","GSM9667823","GSM9667824","GSM9667829","GSM9667790","GSM9667795","GSM9667796","GSM9667830","GSM9667797","GSM9667798","GSM9667831","GSM9667791","GSM9667792","GSM9667793","GSM9667794","GSM9667836","GSM9667837","GSM9667838","GSM9667839","GSM9667832","GSM9667799","GSM9667833","GSM9667834","GSM9667835"],"GPL":["16043"],"GSE":["327889"],"taxon":["Homo sapiens"]}}