{"database":"GEO","file_versions":[{"headers":{"Content-Type":["application/json"]},"body":{"files":{"Other":["ftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE327nnn/GSE327890/"]},"type":"primary"},"statusCodeValue":200,"statusCode":"OK"}],"scores":null,"additional":{"omics_type":["Transcriptomics"],"species":["Homo sapiens"],"gds_type":["Expression profiling by high throughput sequencing"],"full_dataset_link":["https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE327890"],"repository":["GEO"],"entry_type":["GSE"],"additional_accession":[]},"is_claimable":false,"name":"RNA-seq of human synovium from patients with osteoarthritis, rheumatoid arthritis, anterior cruciate ligament rupture, and meniscus tear","description":"RNA sequencing (RNA-seq) was performed on human synovial tissues obtained from patients with osteoarthritis (OA), rheumatoid arthritis (RA), anterior cruciate ligament rupture (ACLR), and meniscus tear (MT) to characterize transcriptional programs associated with synovial pathology. Osteoarthritis is a heterogeneous joint disease exhibiting substantial variability in synovial inflammation, vascularization, and fibrotic remodeling. In this study, synovial tissue samples were collected from patients undergoing joint surgery, and bulk RNA-seq was conducted to profile gene expression across different disease contexts. These transcriptomic data were generated as part of a broader effort to investigate the molecular basis of synovial tissue heterogeneity and its relationship to histological architecture and disease severity.","dates":{"publication":"2026/08/31"},"accession":"GSE327890","cross_references":{"GSM":["GSM9667917","GSM9667918","GSM9667919","GSM9667902","GSM9667924","GSM9667925","GSM9667903","GSM9667926","GSM9667904","GSM9667905","GSM9667927","GSM9667920","GSM9667921","GSM9667922","GSM9667900","GSM9667923","GSM9667901","GSM9667928","GSM9667906","GSM9667929","GSM9667907","GSM9667908","GSM9667909","GSM9667894","GSM9667895","GSM9667896","GSM9667897","GSM9667930","GSM9667893","GSM9667913","GSM9667914","GSM9667915","GSM9667916","GSM9667931","GSM9667898","GSM9667910","GSM9667899","GSM9667911","GSM9667912"],"GPL":["24676"],"GSE":["327890"],"taxon":["Homo sapiens"]}}