{"database":"GEO","file_versions":[{"headers":{"Content-Type":["application/json"]},"body":{"files":{"Csv":["ftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE327nnn/GSE327926/suppl/GSE327926_3Z9XSS-expression-matrix.csv.gz"],"Other":["ftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE327nnn/GSE327926/"]},"type":"primary"},"statusCode":"OK","statusCodeValue":200}],"scores":null,"additional":{"omics_type":["Transcriptomics"],"species":["Mus musculus"],"gds_type":["Expression profiling by high throughput sequencing"],"full_dataset_link":["https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE327926"],"repository":["GEO"],"entry_type":["GSE"],"additional_accession":[]},"is_claimable":false,"name":"PBRM1 RNA-seq [4T1]","description":"Mammalian SWI/SNF or BAF are multi-subunit complexes that regulate cell-type specific gene expression by modulating chromatin accessibility, in coordination with transcription factors and other chromatin regulators. PBRM1 is the complex defining subunit of PBAF class of SWI/SNF complexes. It is mutated in ~40% of clear cell renal cell carcinoma cases but also associated with cancer progression and therapy resistance, indicating context-dependent function. We have previously reported that loss of PBRM1 in normal epithelial cells results in a partial Epithelial-to-Mesenchymal Transition (EMT). In this study, we have utilized epigenomic and transcriptomic approaches to understand the mechanistic role of PBRM1 in EMT-regulated gene expression, and its relationship to genome-wide histone modifications.","dates":{"publication":"2026/06/16"},"accession":"GSE327926","cross_references":{"GSM":["GSM9668752","GSM9668753","GSM9668754","GSM9668755","GSM9668750","GSM9668751","GSM9668749","GSM9668756","GSM9668757","GSM9668758","GSM9668747","GSM9668748"],"GPL":["34475"],"GSE":["327926"],"taxon":["Mus musculus"]}}