GEOapplication/xmlftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE327nnn/GSE327926/suppl/GSE327926_3Z9XSS-expression-matrix.csv.gzftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE327nnn/GSE327926/primaryOK200TranscriptomicsMus musculusExpression profiling by high throughput sequencinghttps://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE327926GEOGSEfalsePBRM1 RNA-seq [4T1]Mammalian SWI/SNF or BAF are multi-subunit complexes that regulate cell-type specific gene expression by modulating chromatin accessibility, in coordination with transcription factors and other chromatin regulators. PBRM1 is the complex defining subunit of PBAF class of SWI/SNF complexes. It is mutated in ~40% of clear cell renal cell carcinoma cases but also associated with cancer progression and therapy resistance, indicating context-dependent function. We have previously reported that loss of PBRM1 in normal epithelial cells results in a partial Epithelial-to-Mesenchymal Transition (EMT). In this study, we have utilized epigenomic and transcriptomic approaches to understand the mechanistic role of PBRM1 in EMT-regulated gene expression, and its relationship to genome-wide histone modifications.2026/06/16GSE327926GSM9668752GSM9668753GSM9668754GSM9668755GSM9668750GSM9668751GSM9668749GSM9668756GSM9668757GSM9668758GSM9668747GSM966874834475327926Mus musculus