GEOTranscriptomicsMus musculusExpression profiling by high throughput sequencinghttps://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE327928GEOGSEfalsePDGF signaling regulates the adipocyte-to-fibroblast transition in wound healingAdipocytes are a plastic cell type with the ability transition into fibroblast-like cells during tissue repair or physiological remodeling. How such transitions are regulated, and whether they exemplify cell plasticity or merely a transient suppression of adipocyte features, is unclear. Fibroblasts express platelet-derived growth factor receptors (Pdgfra and Pdgfrb) while adipocytes express adiponectin (Adipoq). We developed two-step lineage tracing to label Pdgfra+ and Pdgfrb+ cells originating from Adipoq+ adipocytes. Adipocyte-derived Pdgfr+ cells (ADPCs) are induced adjacent to skin wounds and contribute to the wound fibroblast population. ADPCs lose adipocyte characteristics and acquire fibroblast characteristics including collagen expression, smooth muscle actin expression, and cell proliferation. Active PDGFRalpha signaling in ADPCs increases cell proliferation and improves wound angiogenesis and re-epithelialization, while deletion of Pdgfra has the opposite effect. Wound ADPCs persist as fibroblast-like cells after completion of wound healing, indicating an enduring change rather than a transient downregulation of adipocyte characteristics.2026/04/27GSE327928GSM9668810GSM9668816GSM9668815GSM9668817GSM9668812GSM9668811GSM9668814GSM966881334290327928Mus musculus